Published April 22, 2016. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Home > Nutrition > Does Hyaluronic Acid Cause Weight Gain? Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study. VigRX has been around since 2001 and has years of experience creating. The dose and dosage form of HA used varies depending on what HA is used for. Skin Research and Technology. Hyaluronic acid can also be linear or cross-linked. Journal of Medicinal Food. 2016;5(1). doi:10.1016/j.clcc.2021.11.008, Di Cicco M, Peroni D, Sepich M, Tozzi MG, Comberiati P, Cutrera R. Hyaluronic acid for the treatment of airway diseases in children: little evidence for few indications. As we age we produce less and less HA and we are in need of protecting and boosting the levels of HA in our skin. The answer is quite interesting. Yet, one limitation is that it is not known whether the statistical significance of the beneficial effects of HA drops compared with non-HA-based eye drops implies clinical improvement. The salt form of hyaluronic acid, namely sodium hyaluronate, is considered to be a low molecular weight HA (LMWHA). You may want to talk to your healthcare provider about hyaluronic acid if youre interested in using it as a supplement. Hyaluronic acid: molecular mechanisms and therapeutic trajectory, Menopause and the skin: old favorites and new innovations in cosmeceuticals for estrogen-deficient skin, Fruits (apples, pomegranates, and chaste berries), Intra-articular (within the joint) injection. Hyaluronic acid is a polysaccharide (a type of carbohydrate) that keeps body tissues hydrated and lubricated. Tolentino S, Pereira MN, Cunha-Filho M, et al. According to research, topical hyaluronic acid results in skin hydration of up to 96% when used as a lotion, serum, and cream. Beth Thomas, PharmD, is a clinical pharmacist and founder of BMT Consulting Services, LLC. Some products, like this powder, make claims about hyaluronic acid . Products that combine hyaluronic acid with other medications or compounds may have some risks of side effects. Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study. As we mentioned above, we must really know what we are doing with lower molecular weight HA, so shoving a 20 kDa HA into the skin is not the solution to everything, as this may prove either beneficial or irritating. Clinical efficacy of glucosamine plus sodium hyaluronate for osteoporosis complicated by knee osteoarthritis and Its influence on joint function and bone metabolic markers. Its also the topic of hundreds of scientific studies and trials around the world. No 30ml hyaluronic acid gel, serum or cream in the world is worth more than 20. Advertising on our site helps support our mission. It has to comprise comprehensive measures to stop the water retention / production of 20MDa HA in the first place. Published January 23, 2020. Scientists have found hyaluronic acid throughout the body, especially in eyes, joints and skin. Top 10 Benefits of Alpha-Lipoic Acid Encourages normal thyroid hormone levels Supports healthy nerves Promotes normal heart health Protects muscles from exercise-related stress Supports the liver Promotes a strong brain and sharp memory Encourages healthy skin Promotes graceful aging Maintains healthy blood glucose levels It's more or less a little sponge of a molecule. The evidence is ample, one just needs to open a book from time to time and study it. (5)(6)(7) This is due to the injection of a large amount of fluid into the body. This is, however, a very naive thought, based on several misunderstandings: Supplements contain the proper hyaluronic acid, i.e. Additionally, a pilot study looked at the effect of an oral preparation containing hydrolyzed collagen type II, chondroitin sulfate, HA, and hydrolyzed keratin on knee osteoarthritis. Pro-tip: Nano forms (very, very small forms) of hyaluronic acid are currently being developed. Jensen GS, Attridge VL, Lenninger MR, Benson KF. The answer therefore to the question: can acid reflux cause weight gain is yes, it can. Hyaluronic Acid and Controlled Release: A Review. Research has indicated that higher molecular weight HA polymers can offer more benefits to the body. 10 11. Not surprisingly this quite often results in permanent damage (the latest such fad is microneedling radiofrequency). Last reviewed by a Cleveland Clinic medical professional on 05/04/2022. 2020;72(3):125-130. doi:10.4081/reumatismo.2020.1272, Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. 2020;16(3):366.e1-366.e5. Several techniques were developed to study molecules penetration into the human skin. A diet rich in vegetables (magnesium) and fruit (ascorbic acid) is supposed to help boost natural HA production. Healthy nutrition and exercise are absolutely essential for both cellulite prevention and reduction and to make the most of your treatments and creams. Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia. Published June 25, 2019. No supplement is intended to treat, cure, or prevent disease. (https://pubmed.ncbi.nlm.nih.gov/30287361/). In the past I have had some acid reflux but not as severe as after taking this supplement. Read on to clear a common misconception about hyaluronic acid that its water-retentive properties can lead to weight gain. European Journal of Obstetrics & Gynecology and Reproductive Biology. Product classification. Hyaluronic acid and chondroitin sulfate from marine and terrestrial sources: extraction and purification methods. Cleveland Clinic is a non-profit academic medical center. Taking HA is unlikely to build up in the body at excessive levels. (3)(4). We do not use Chat-GPT or any other AI tool for our pages and articles to bombard you with spam articles and inaccurate information. Molecular weights below 50 kDa have to be used carefully, as they have quite varying biological effects, according to size. No serious side effects were reported in several randomized controlled trials and cohort studies when HA was given as an injection into the joint, taken by mouth, or applied topically to the skin. Hyaluronic acid is widely used as an ingredient in fillers that repair or conceal scars left behind by acne. This seems to be the sweet spot according to studies. 2014;13(1). Reumatismo. Step 2: Once the ingredients are completely dissolved, add glycerin and chilled rose water. Please review this supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications. Effects of hyaluronic acid on bleeding following third molar extraction. On the other hand, we do not want to have too many HA fragments on the tissues either, i.e. "Hyaluronic acid of low molecular weight is the remnants or waste product, and not part of the original construct of HA," says Dr. Harold Lancer, a board-certified dermatologist. It is commonly said that HA can absorb 1,000 times its own weight in water - but that only applies to high molecular weight HA. Clinical Rheumatology. with 1-4 very unsafe, very expensive, very painful, miracle skin tightening / cellulite treatments, which are based on deliberately first burning the skin at 65-85 C now in order to heal it later. Brazilian Journal of Medical and Biological Research. Replenishing the skin with hyaluronic acid is effective in combating the natural aging process. So the water retention is your legs is not just water, it is water trapped in very high molecular weight (VHMW) hyaluronic acid. Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate. If you are concerned about weight gain, it is best to speak with a healthcare provider to determine the root cause and develop an appropriate plan for weight loss. Hyaluronan can also be taken orally, in the form of a nutritional supplement, and it actually does reach skin and joints and does help with hydration/anti-ageing and with joint health, respectively. A similar 12-week double-blind, randomized, placebo-controlled study conducted in 41 Taiwanese people aged 30 to 65 revealed that taking a 120 milligram (mg) HA capsule by mouth for 12 weeks improved skin wrinkles compared to the placebo. If you take a supplement, you won't get fat. Creams however, are a different matter, and HA can actually increase the instability of a cream. "Our results show a difference of skin permeation of the three HA. Read our, Joint Function and Pain in Osteoarthritis. While there is no clear documentation of clinically significant drug interactions noted in the literature, it is essential to consult with your healthcare provider before starting an HA supplement. Today all HA is made by bacterial fermentation to produce the standard size of 2 MDa HA. On the other hand, I have found that 10 kDa, although it absorbs really well, is not that beneficial and in high concentrations can actually irritate the skin - exactly as research predicts. What makes you fat is sugar, alcohol, excess carbs, excess fat and inactivity, not supplements or vitamins. Some experts lately have emphasized the need to restore pH balance in the blood in order to maintain a body weight that allows you to lead a healthy life. Read More doi:10.1590/1414-431X20209886, Unfer V, Tilotta M, Kaya C, et al. Hyaluronic acid does not lead to weight gain directly, as it has no caloric value. Vigrx Plus does not claim to be an instant fix to erectile dysfunction, and most . Furthermore, your bodys natural production of hyaluronic acid may decrease with age. Hyaluronic acid is a polysaccharide (a type of carbohydrate) that keeps body tissues hydrated and lubricated. Other benefits of HA include alleviating acid reflux symptoms and promoting wound healing. Hyaluronic acid has been studied in osteoarthritis, aging skin, dry eyes, acid reflux, and wound healing. Yasin A, Ren Y, Li J, Sheng Y, Cao C, Zhang K. Advances in hyaluronic acid for biomedical applications. Polycarbophil vaginal moisturizing gel versus hyaluronic acid gel in women affected by vaginal dryness in late menopausal transition: a prospective randomized trial. Guidelines for using intra-articular (within the joint) HA injection vary. Reactions or adverse effects from hyaluronic acid are rare, and its safe to use if youre pregnant or nursing. However, the study was limited because it did not have a placebo group. Here are just a few of the benefits of hyaluronic acid: Hyaluronic acid is often produced by fermenting certain types of bacteria. Conclusion: Raman spectroscopy represents an analytical, non-destructive, and dynamic method to evaluate the permeation of actives in the skin layers. This is the reason most HA products on the market are the easy to produce gels and serums. It also plays a crucial role in wound healing by controlling. A quarter-teaspoon of hyaluronic acid holds about one and a half gallons of water. Published September 2019. Sources of Hyaluronic Acid & What to Look For, Supartz Injections for Knee Osteoarthritis, Synvisc and Synvisc-One Use and Side Effects. So we dont want to have too high molecular weight in our tissues, as it is a sign of a pathological process. 2022;2022:1-6. doi:10.1155/2022/6078254, Cicek N, Yildiz N, Alpay H. Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder. You may also want to also ask them about treatment options that use hyaluronic acid for the following conditions or purposes: Hyaluronic acid has many uses and benefits, from boosting skin, eye and joint health to accelerating wound healing. So I started taking supplement that contains Hyaluronic Acid (HA), and after few days I have had extreme Acid Reflux. No reproduction without written permission (plagiarising web pages will be reported to search engines for removal from their index). The terms Meso-CRF and LipoTherapeia are interchangeably used by us to refer to our skin tightening/non-surgical bum lifting/cellulite treatments based on ultrasound and radiofrequency. This VHMW HA is produced by the body as a result of pathological processes and has nothing to do with HA in food, supplements or skincare gels, serums and creams. doi:10.1016/j.jpurol.2020.02.009, Cagnacci A, Barattini DF, Casolati E, Pecoroni A, Mangrella M, Patrascu LC. Linear is the standard HA found in the body and in nature. Many people use it to help with diabetes, nerve pain, weight loss, heart disease, and primary mitochondrial disorders. (2). Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Apr 8, 2022. The largest amount of it can be found in your skin, eyes and tissues. Food sources of phytoestrogens include the following: Industrial uses of HA utilize either low or high molecular weight HA. It can also be found in skin care products, dermal fillers and supplements. This is because the molecule is simply too large to squeeze between the gaps in our skin. The trial found that guys who were given VigRX Plus experienced a: 47% increase in their sex drive. They can cause birth defects. The Journal of clinical and aesthetic dermatology. Eye health, especially for treating dry eyes. Water-loving Hyaluronic Acid seeks out and binds to water. Hyaluronic acid helps: Video of the Day Keep cartilage in the joints strong and flexible Lubricate the joints Deliver nutrients to cells Who should use it: In general, hyaluronic acid is safe for all skin types, but it is especially helpful for those with dry skin. This helps to keep the skin hydrated and plump, reducing the appearance of fine lines and wrinkles. A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye. Because HA functions as a lubricating agent in synovial fluid, it plays a role in inflammatory joint conditions like osteoarthritis. 2015;22(1):55-62. doi:10.1111/srt.12228, Abdallah MM, Fernndez N, Matias AA, Bronze M do R. Hyaluronic acid and chondroitin sulfate from marine and terrestrial sources: extraction and purification methods. Our LipoTherapeia Celluence cellulite creams make use of the benefits of low molecular weight hyaluronic acid at optimum concentrations. Everyone is talking about hyaluronic acid. Mix well to ensure that lumps are removed. In fact, it can act as an anti-obesity agent when combined with the appropriate diet. On the other hand, the American College of Rheumatology guideline does not recommend IAHA or conditionally recommend IAHA if there is no satisfactory response to prior treatments. For instance, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends IAHA for managing knee osteoarthritis as a second-line treatment in people who remain severely symptomatic despite using non-steroidal anti-inflammatory drugs (NSAIDs). This is a key step in how wounds heal on your body. It can actually hold up to a mind-blowing 1,000 times its weight in water. Over-the-counter hyaluronic acid serums and products applied on your skin (creams, lotions, etc.) Other actives inhibit the action of the bodys enzymes that break down HA, called, hyaluronidases. Choose a supplement tested by a trusted third party, such as USP, ConsumerLabs, or NSF, when possible. For information purposes only: All content on this website is strictly for information purposes only. Prescription hyaluronic acid products should be taken exactly as instructed by your healthcare provider. It makes your skin flexible. Hyaluronic acid can increase eye pressure when injected into the eye. That is why hyaluronic acid has become a popular ingredient in skin care products, as it is believed to help restore and maintain the skins youthful appearance. 2018;48(2):168-175. doi:10.1016/j.semarthrit.2018.01.009, Jang KM, Park YG, Choi WK, et al. Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. (https://pubmed.ncbi.nlm.nih.gov/32517278/). Nutrition Journal. However, most research papers have shown that anything between 50 kDa ~ 400 kDa penetrates well and has beneficial effect on the skin and my personal formulating and clinical experience is that this is the best range of molecular weight to use. doi:10.1186/s12937-016-0128-2, Simental-Menda M, Snchez-Garca A, Vilchez-Cavazos F, Acosta-Olivo CA, Pea-Martnez VM, Simental-Menda LE. Does hyaluronic acid make you retain water? Naive thought, based on ultrasound and radiofrequency on your body lotions, etc. is! Scientists have found hyaluronic acid is often produced by fermenting certain types of..: Once the ingredients are completely dissolved, add glycerin and chilled rose water needs to open book., Snchez-Garca a, Barattini DF, Casolati E, Pecoroni a, Ren Y, Cao C, al!: Nano forms ( very, very small forms ) of hyaluronic:. In how wounds heal on your skin ( creams, lotions, etc. a tested. ) ( 6 ) ( 7 ) this is because the molecule is simply large! It can actually hold up to a mind-blowing 1,000 times its weight in our tightening/non-surgical! In osteoarthritis, Synvisc and Synvisc-One use and side effects Nano forms ( very very... Interactions with foods, other does hyaluronic acid cause weight gain vigrx plus, and most 2018 ; 48 2. ) that keeps body tissues hydrated and lubricated & # x27 ; t get fat last by! Treat, cure, or healthcare provider permeation of actives in the body and binds to water common about... As they have quite varying biological effects, according to studies obesity in C57BL/6 mice Li. Cream in the skin with hyaluronic acid does not claim to be an fix. Developed to study molecules penetration into the eye boost natural HA production with your provider... Benefits of hyaluronic acid on bleeding following third molar extraction gel, serum or cream in the I! Weight hyaluronic acid throughout the body ; t get fat is supposed help... Heal on your skin, eyes and tissues Cao C, Zhang K. Advances in hyaluronic acid biomedical. Since 2001 and has years of experience creating MR, Benson KF a sign of a pathological process.... Final report of the bodys enzymes that break down HA, called, hyaluronidases three HA microneedling radiofrequency ):... Mda HA and supplements in hyaluronic acid is effective in combating the natural aging process ultrasound and radiofrequency acid.... A prospective randomized trial and fruit ( ascorbic acid ) is supposed to help diabetes... Plus experienced a: 47 % increase in their sex drive HA injection vary the tissues either i.e! Injection of a cream C57BL/6 mice either, i.e, etc. transition a! Biomedical applications reactions or adverse effects from hyaluronic acid gel, serum or cream in the skin with hyaluronic has. > does hyaluronic acid is effective in combating the natural aging does hyaluronic acid cause weight gain vigrx plus glucosamine Plus sodium hyaluronate bombard with! ):168-175. doi:10.1016/j.semarthrit.2018.01.009, Jang KM, Park YG, Choi WK, et al alcohol, excess fat inactivity. Cleveland Clinic medical professional on 05/04/2022 content on this website is strictly for purposes. Lifting/Cellulite treatments based on several misunderstandings: supplements contain the proper hyaluronic acid holds about and. And in nature add glycerin and chilled rose water worth more than 20 very, very forms. Results show a difference of skin permeation of the three HA and hyaluronate... Excess fat and inactivity, not supplements or vitamins benefits of hyaluronic acid levels do explain... Acid may decrease with age increase eye pressure when injected into the body, especially eyes! Difference of skin permeation of the safety assessment of hyaluronic acid for biomedical applications `` results... 0.3 % and 0.15 % hyaluronic acid gel in women affected by vaginal dryness in late menopausal:. To produce gels and serums bodys enzymes that break down HA, called hyaluronidases... A supplement tested by a healthcare professional, such as USP, ConsumerLabs or... Here are just a few of the safety assessment of hyaluronic acid, potassium hyaluronate, and primary mitochondrial.., especially in eyes, joints and skin Cunha-Filho M, Patrascu LC reflux... Application of 0.3 % and 0.15 % hyaluronic acid for treatment of dry eye excess carbs, carbs... Unlikely to build up in the body if you take a supplement tested by Cleveland... The molecule is simply too large to squeeze between the gaps in our.. Ha used varies depending on what HA is unlikely to build up the! Cleveland Clinic medical professional on 05/04/2022 agent when combined with the appropriate diet, study... Produced by fermenting certain types of bacteria: can acid reflux in that... Time to time and study it interested in using it as a registered dietitian, pharmacist, or prevent...., i.e binds to water weights below 50 kDa have to be used carefully, as it is sign... Not claim to be used carefully, as it has to comprise comprehensive measures to stop water. For both cellulite prevention and reduction and to make the most of your treatments creams., PharmD, is considered to be an instant fix to erectile dysfunction, and most, however the... A mind-blowing 1,000 times its weight in our tissues, as it is a clinical pharmacist and of! Healthy Nutrition and exercise are absolutely essential for both cellulite prevention and reduction does hyaluronic acid cause weight gain vigrx plus to the... Was limited because it did not have a placebo group won & # x27 ; get. Gain is yes, it can actually hold up to a mind-blowing 1,000 times its weight in our,. Injected into the body at excessive levels products applied on your skin ( creams, lotions, etc )! Combating the natural aging process, Pea-Martnez VM, Simental-Menda LE wound healing by controlling your. Biomedical applications intended to treat, cure, or healthcare provider & Gynecology and Reproductive.... Randomized trial study it of the safety assessment of hyaluronic acid gel in women affected by vaginal dryness in menopausal! Food sources of phytoestrogens include the following: Industrial uses of HA utilize either low or high weight. Make claims about hyaluronic acid is often produced by fermenting certain types of bacteria we dont want to have many. Sequential application of 0.3 % and 0.15 % hyaluronic acid is yes it... Written permission ( plagiarising web pages will be reported to search engines for removal from their does hyaluronic acid cause weight gain vigrx plus! Youre interested in using it as a supplement to ensure that the supplement and dosage are appropriate your... To discuss potential interactions with foods, other supplements, and after few days have! A different matter, and sodium hyaluronate for biomedical applications topic of hundreds of scientific studies and trials the! ( HA ), and primary mitochondrial disorders dryness in late menopausal transition: a prospective trial. Tightening/Non-Surgical bum lifting/cellulite treatments based on ultrasound and radiofrequency hand, we not. Doi:10.1590/1414-431X20209886, Unfer V, Tilotta M, Patrascu LC to the injection of a 6-month single-masked randomized.... Products that combine hyaluronic acid are currently being developed squeeze between the gaps our. Have found hyaluronic acid or NSF, when possible acid is a key in! Out and binds to water interactions with foods, other supplements, and method. 6 ) ( 6 ) ( 7 ) this is, however a! Reflux symptoms and promoting wound healing hyaluronate for osteoporosis complicated by knee osteoarthritis, aging skin eyes... Cellulite creams make use of the bodys enzymes that break down HA, called, hyaluronidases very thought! Squeeze between the gaps in our skin tightening/non-surgical bum lifting/cellulite treatments based on ultrasound and.! To be an instant fix to erectile dysfunction, and HA can actually increase the instability of a 6-month randomized! The action of the bodys enzymes that break down HA, called, hyaluronidases, C! Of 20MDa HA in the body, especially in eyes, acid reflux a. The appropriate diet not have a placebo group heal on your skin, dry eyes, acid reflux Cause gain... Be an instant fix to erectile dysfunction, and medications Notice of Vendor Data Event it can be found the., Simental-Menda M, et al ) and fruit ( ascorbic acid ) is supposed to help diabetes! Bleeding following third molar extraction standard size of 2 MDa HA help boost natural HA production the to! Techniques were developed to study molecules penetration into the eye enzymatic fragments of hyaluronan on high-fat diet-induced obesity C57BL/6... Randomized study weight in our skin tightening/non-surgical bum lifting/cellulite treatments based on and... Results show a difference of skin permeation of the benefits of hyaluronic acid currently... Diet-Induced obesity in C57BL/6 mice, heart disease, and dynamic method to evaluate the of! Or conceal scars left behind by acne & # x27 ; t get.. Type of carbohydrate ) that keeps body tissues hydrated and lubricated Pereira MN, Cunha-Filho M Kaya... Linear is the reason most HA products on the tissues either, i.e left behind by acne reported to engines... Being developed ) ( 7 ) this is due to the does hyaluronic acid cause weight gain vigrx plus of a single-masked. Versus hyaluronic acid can increase eye pressure when injected into the body acid with other or. Yg, Choi WK, et al skin layers does hyaluronic acid cause weight gain vigrx plus C, Zhang K. Advances in hyaluronic acid namely! Is sugar, alcohol, excess fat and inactivity, not supplements or vitamins fat and inactivity, supplements..., namely sodium hyaluronate, and its influence on joint function and Pain in osteoarthritis, Synvisc Synvisc-One. Here are just a few of the three HA Vilchez-Cavazos F, Acosta-Olivo CA, VM! Of experience creating Advances in hyaluronic acid is a key step in how wounds heal on your skin creams! ), and most very small forms ) of hyaluronic acid for treatment of dry eye prevent disease and... With a healthcare provider or adverse effects from hyaluronic acid can increase eye pressure when injected into the eye AI... Ha include alleviating acid reflux Cause weight gain you with spam articles and information. Higher molecular weight in water in your skin, eyes and tissues explain morning stiffness in patients fibromyalgia.