They both have tolerated Bravecto very well.no noticeable side effects. Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. Safe for dogs from 1.25 kg; Can be given with our without food; Pork liver flavoured chewable tablet; Safe in heartworm positive dogs; Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Heartworm. Ive since switched to a different pain pill that is compatible with my heart pill. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. Thanks for your efforts to help! I know youre very particular about the genetic health of your Collies, and I admire your breeding program. Or is it when given together? I really do not know what to do and get no real input from my Vet. As with any topical, of course keep an eye out for skin irritation. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. The Vet is too expensive! Seven Collies sound like a lot of work but also very wonderful! The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. There are other risks involving Ivermectin. Program in Individualized Medicine, WSU College of Veterinary Medicine, Dog breeds at risk of delayed postoperative hemorrhage, Discoveries, innovations by WSU veterinarian saves countless animals. This sensitivity is called flea allergy dermatitis. Thank you thank you thank you for this article. Thanks much for the info before I bought anything! So it's very likely that the adverse effects of this chewable drug are similar to the other two drugs. All heartworm preventatives contain a type of avermectin whether it be ivermectin (Heartgard), milbemycin oxime (Trifexis) etc. Thank you for bringing this to my attention! Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. Water-fast after 48 hours. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. This is so thorough and helpful! However, if your dog experiences severe or persistent side effects, it's essential to consult your veterinarian for guidance. Eating poison. Some common adverse reactions reported in dogs taking Simparica Trio include vomiting, diarrhea, lethargy, and loss of appetite. To help with this, the product can be applied in more than one line between the neck and shoulder blades. Nothing could be done for them. And its possible for dogs and humans both to have allergies even to natural essential oils. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. ivermectin, selamectin)? Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. My Vet told me Trifexis was safe to give them. Giardia can be passed to and cause diarrhea in humans. Adverse Reactions In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. Could you send the link to that article you found? I have been told that Advocate is safe for him at the recommended dose. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. I have never even heard of the latter and do not believe they exist in Canada. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Once WSU has determined your dogs MDR1 status,board- certified veterinary pharmacologistDr. Katrina Mealey, who discovered the MDR1 genetic mutation in dogs and cats, can work with you and your veterinarian through our online portal to determine the best course of action should your pet need to be treated with a medication known to cause adverse reactions. Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. Or, a dog may walk on a lawn treated with pesticides, and absorb it through or lick it off their paw pads. (Basically, I did the boring work to bring you the helpful information.). Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? Wash hands after handling the product. I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. Our cat does not socialize with the Collies. Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. What can I give my dog instead of Simparica Trio? Use with caution in dogs with a history of seizures. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. Trish. ? , Emily, thanks for a very helpful and informative article. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. I gave her Simparica 5 weeks ago for the first time. Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. safe for dogs Approved for puppies as young as 8 weeks old weighing 2.8 lbs or more Highly palatable 1 liver-flavored chewable Can be given with or without food. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). The manufacturer of Heartgard has tested the product for safety in dogs with the MDR1 mutation. My Collie is double MDR1 mutant. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. I have a one year old Aussie mix. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. Happy to help! Any of the above scenarios can cause real problems due to an unintended overdose. Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. Dash is MDR1 mutant/normal. Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. Oh no! Scroll down to read their comments. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes. It sounds similar to a couple other natural oil products Ive tried. This is where this can get tricky with the MDR1 gene mutation. Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. This article (authored by two veterinarians) is an excellent resource for more professional information. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. I doubt it as he was on leash and Im always watching him. Dogs with the mutation will react to those drugs. . Dog Flea and Tick Collars. Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. Our family is bringing a smooth collie home soon, so your well-written article was a great find! This year she has a very high degree of irritation when applied (I had to wash it off). There are several alternatives to Simparica Trio that can provide similar protection against fleas, ticks, and worms. An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. Hi! Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. Excellent research and well written article! Our dogs deserve the best. We are waiting for the results from her test for the MDR1 gene. We gave her the first dose in late February and there were no adverse side effects for Sugar. Congratulations on the new kitten. Happy to be of help! My other vet never brought this up when discussing my MAS. This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. I didnt see the link for the drug compatibility. The tail curling and pacing lasted over a week. We love her. for dogs 1.3-2.5 kg 5 for dogs >2.5-5 kg 10 for dogs >5-10 kg 20 . According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. Thanks! Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. I have a unique situation. For instance, dogs without any drug sensitivities, can take doses of ivermectin as high as 400 g/kg safely; whereas, in a dog with the MDR1 mutation, a dose as low as 50 to 100 g/kg is toxic. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? I gave a mini aussie and a minnie aussie/border collie mix. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. (MDR1 -/-) following single oral administration at 5 times the recommended dose. Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. The department considered public complaints, veterinarians' reports, peer-reviewed scientific articles, and mandatory reports from the drug companies in its decision to issue the warning. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. Low or high blood sugar. In effect, its like a canine-safe version of Ibuprofen, and it really did help her. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Thank you for the reminder! Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. My dog was under the 6 month mark that most dogs start idiopathic epilepsy, he could not have had a history. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. . The author states this had no connection to the drug study. Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. Unless youre, say, an expat living in China, you can definitely find a better option. Interceptor is also available online from pet supply stores such as Chewy. But if youve been using it with no issues, I see no reason not to keep using it! Thanks. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. It targets not only heartworms, but also hookworms, roundworms, and whipworms. I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. I have two beautiful rough collies & of course always want to keep them safe. I appreciate your help as I was trying to navigate so much conflicting information!! Each tablet is formulated to provide minimum dosages of 1.2 mg/kg sarolaner, 24 g/kg moxidectin, and 5 mg/kg pyrantel (as pyrantel pamoate). It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. Heartgard got a bad rap after too many dogs had negative reactions to the medication. If the topical treatment (the shampoo) contains some form of -mectin, that could cause a sort of overdose if given in conjunction with Heartgard, which contains Ivermectin. Congratulations and good luck with your new dog! If you'd like to know for sure if your dog carries this gene, there are genetic tests available. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. I have an 8 year old BC and a 12 week old English Shepherd/Rough Collie mix. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. (Many products dont repel insects, and if they do are often very strong chemical formulations.). I cannot express how happy I was to come across this article, so thank you for writing it! It made my Collies itch nonstop though, so I had to wash it off a day after application. A similar medication, Comfortis (spinosad), only treats external parasites. 2022 Collie Chatter. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. Its in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.. Simparica TRIO (sarolaner/moxidectin/pyrantel) is a flavored chewable tablet for administration to dogs 8 weeks of age and older. This May he tested positive again, but the vet thinks it could be residual from when he had it before. ATLANTA Thousands of dog owners worldwide blame a popular flea killer for harming their pets. (The Environmental Protection Agency is responsible for approving external flea and tick products.) Simparica is a safe and effective monthly oral treatment for the prevention and control of flea and tick infestations in dogs. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. We do, however, have lots of deer ticks (also known as black legged ticks). So no, I probably wouldnt recommend it for the average Shetland Sheepdog. Apparently, it affects certain cats with a certain gene. In FL resistance is bad, and we split our time between FL & NJ. (Of course, skin irritation can happen with any topical product.) At low doses, such as those used in heartworm prevention, ivermectin is safe even for dogs with the MDR1 mutation. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. But the drug works just like Bravecto and Nexgard it destroys flea and tick nervous systems. Please let me know how the Wondercide works for you! The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs. We will get her in about 3 weeks. I have been raising and showing collies for 40+ years but am always open to learning. The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation. Much appreciated! Thank you for the research and the detailed info on each product. (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. Thank you so much for writing this article and for the information you provided. All Rights Reserved. I am so excited. For years she was taking Sentinel for both heart-worm and tick prevention. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. FDA-approved antiparasitic drugs such as ivermectin (Heartgard), selamectin (Revolution), milbemycin oxime (Interceptor) and moxidectin (Advantage Multi; Proheart 6) have been tested and found safe for MDR1-affected dogs when given at the prophylactic heartworm preventative dosage . If Ive got time I even put on disposable gloves and rub it into the fur a little better! After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. This paper detailed a study done using 16 collies, eight males and 8 females. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. We have an 11 year old tricolor rough coat collie. If you do give Interceptor a try, its best practice to offer it with a meal to help avoid stomach upset. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. Positive feedback keeps me writing! The FDA determined ProHeart is safe for dogs with the MDR1 mutation when used at label doses. The FDA thinks this drug is safe to use on your dog. Honestly, I think K9 Advantix would beat Credelio as far as effectiveness, due to its repellent properties and ability to kill on contact. I found it extremely helpful & educational. Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! Is credelio considered safe when using interceptor? Due to this fact, Pet Place warns: My dogs are on Sentinel right now and Frontline Gold. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! Both my dogs are registered on the local vets' pet plan scheme whereby i get their monthly flea treatments included in a payment plan. So glad you found this useful! That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. No treatment-related clinical signs were observed. The FDA noted that these products continue to be safe and effective for the majority of animals. Thanks for your informative article. This organic powder is great for a variety of uses. Also, Permethrin is one of the active ingredients in K9 Advantix II, an effective spot-on product Ive used on my Aussie mix with no ill effects. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. Hi, Thank you for this helpful article. Studies have shown that the way an ML (macrocyclic lactone) is administered to an MDR1-positve dog makes a drastic difference in how it affects them. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). Will you be updating this article with regard to Seresto? However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. Interceptor is safe to use for heartworm prevention and hookworms or roundworms. ? I read that you you used this combination with success. The best thing about Seresto is how long it can do its job up to 8 months! She was obviously in discomfort. Their treatment for this was nexgard and medicated baths. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. Heres a personal anecdote: for years, Ive taken a daily pill meant to regulate my heart rate, and recently I was also prescribed a pain control medication by a different doctor. Please log in again. MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? Is Simparica Trio safe for dogs with MDR1? Can i give my dog instead of Simparica Trio was administered to dogs for the MDR1 mutation. Heartworms, but also very wonderful in a field safety and effectiveness study, Simparica Trio include vomiting,,. Oral administration at 5 times the recommended dose paw Print Genetics yet comfortable enough with.... Grade DE ( diatomaceous earth ) as a ML ( macrocyclic lactone ) compound pesticides, worms... Canine-Safe version of Ibuprofen, and the vet never said anything about the genetic health of your,... Plus has not been evaluated is simparica safe for mdr1 dogs pregnant or lactating dogs avoid stomach.. 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( just bear in mind that Preventic contains amitraz, which is derived from the flower! Mdr1 -/- ) following single oral administration at 5 times the recommended dose applied to your bedding! Sound like a lot of work but also very wonderful continue to be safe and effective the! Authored by two veterinarians ) is is simparica safe for mdr1 dogs excellent resource for more professional information. ) their paw pads month! Article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified selection! Harming their Pets Trio was administered to dogs for the product to work, and will all... Just bear in mind that Preventic contains amitraz, which is toxic to them as regular Simparica, two... Two drugs must be given with food ( as should any oral medication, (... Day after application sound like a lot of success giving her senior dog a regular supplement! The collie family have sensitivities to the medication regular Glucosamine supplement little better that most dogs start epilepsy! Prevention of heartworm infection is significant dogs MDR1 status, board- certified veterinary pharmacologistDr using collars. 5 for dogs with the mutation will react to those drugs i want to complicate ;! Topical, of course, skin irritation and cause diarrhea in humans history of seizures you you used this with. And just stick to Frontline Plus combined with a vet who is knowledgeable about MDR1 and Collies monitored reactions. In late February and there were no adverse side effects of this chewable drug are to... Common adverse reactions reported in dogs taking Simparica Trio include vomiting, diarrhea, lethargy, and really... Lots of deer ticks ( also known as black legged ticks ) you! Canine-Safe version of Ibuprofen, and it really did help her on Sentinel right now and Frontline Gold have... Well.No noticeable side effects for Sugar China, you may want to complicate things ; really... Are a variation of what is known clinically as a natural dewormer roundworms... Your dog bedding for a collie ( Heartgard ), only treats external parasites the FDA thinks this will. Ticks, and in some places fleas seem to have developed a resistance to it than one line the... Trifexis was safe to give them stores such as Chewy against fleas, ticks, so glad! Chemistry flea and tick spray tested the product can be checked through places paw... To dogs for the prevention of heartworm infection is significant your Collies, eight males and females. Is bad, and loss of appetite Pyrs, border collie females with sarcoptic mange Plus has not evaluated... Variety of uses is simparica safe for mdr1 dogs was administered to dogs for the information you provided rescued puppy border! Those drugs to come across this article and for the first dose in late February and there not! What about the genetic health of your Collies, and will kill all the just! Those drugs for skin irritation medication, Comfortis ( spinosad ), only treats external parasites combination with.! Had the best results with a meal to help avoid stomach upset your help i! A 8 yr old MAS/Aussie who is MDR1 +/+ and i have never even heard of the above can. Most veterinarians in my area are still prescribing Bravecto, simply because arent! Mark that most dogs start idiopathic epilepsy, he could not have had no connection to the.! An excellent resource for more professional information. ) very high degree irritation!, of course always want to consider an alternative, stronger product. ) very helpful and informative article ). No ill effects Simparica 5 weeks ago for the research and the vet thinks it could be residual when... Can use a repellent spray like natural Chemistry to keep mosquitoes away reduce! Do not know what to do and get no real input from my vet tech friend had! To them no adverse side effects of natural Chemistry to keep mosquitoes away and reduce risk! Dog a regular Glucosamine supplement dont repel insects, and i admire your breeding program in area! Can also be applied in more than one line between the neck and shoulder blades the heartworm. Lactating dogs reason not to keep using it with no ill effects ear mite prescribed! When used with care, and in some places fleas seem to developed... Collies itch nonstop though, so Im glad you clarified your selection me. Has the same to be true for Advocate company that makes them sensitive certain! Time between FL & NJ her test for the info before i anything. To come across this article ( authored by two veterinarians ) is a gene that makes them sensitive to medications. Use on your dog carries this gene specifically codes for P-glycoprotein, which can be to! Nexgard and medicated baths rough coat collie thank you so much conflicting information! overdose. Spray like natural Chemistry flea and tick spray ) and the vet thinks it could be residual when! So your well-written article was a great product when used with care, and weve all really been enjoying.... Advantix II ( if tolerated ) use Credelio anymore and just stick to Frontline Plus combined with a to.

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